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Profile ( English version )

Takao Shimizu, M.D. Ph.D.
Professor
Department of Biochemistry and Molecular Biology
Dean
Faculty of Medicine, The University of Tokyo
Bunkyo-ku, Tokyo 113-0033, Japan
Phone 81-3-5802-2925
Fax 81-3-3813-8732
e-mail:tshimizu@m.u-tokyo.ac.jp

Nationality: Japan
Date of birth: April 26, 1947
Place of birth: Tokyo, Japan
Marital status: Married, two children, two grandsons
Present address: Honkomagome 2-18-2-103, Bunkyo-ku, Tokyo 113, Japan

Education

  • 1965-1968 Undergraduate, Faculty of Liberal Arts, The University of Tokyo<
  • 1968-1973 Undergraduate, Faculty of Medicine, The University of Tokyo<
  • March 28, 1973 M.D.<
  • 1973-1975 Clinical Training in Internal Medicine, The University of Tokyo Hospital<
  • 1975-1977 Postgraduate research training in Biochemistry, Kyoto University<
  • February 16, 1980 Ph. D. degree (Medical Science)<

Professional Record

  • 1977-1982 Assistant Professor in Medical Chemistry , Kyoto University School of Medicine, Kyoto (Osamu Hayaishi)<
  • 1982-1984 Visiting Scientist at Department of Chemistry, Karolinska Institute, Stockholm (Bengt Samuelsson)<
  • 1984-1991 Associate Professor in Physiological Chemistry and Nutrition, Faculty of Medicine, The University of Tokyo<
  • 1991-Present Professor, Department of Biochemistry, Faculty of Medicine, The University of Tokyo<
  • 2003- Vice Dean of Faculty of Medicine, The University of Tokyo, Director of Institute for Disease Biology and Integrated Medicine, Faculty of Medicine, The University of Tokyo.<
  • 2004- Research advisor for the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan<
  • 2007- Dean, Faculty of Medicine<

Award

  • The Research Promotion Award from the Japanese Biochemical Society (1981)<
  • Ermst Schering Prize, Germany (2000)<
  • Prize from Japanese Medical Association (2000)<
  • Mochida Award for Science and Technology, Japan (2001)<
  • Takeda Medical Award , Japan (2003)<
  • Uehara Memorial Award (2004)<
  • Japan Academy Prize (2009)<

Membership of Academy Society

  • Japanese Biochemical Society<
  • Japanese Society of Molecular Biology<
  • Japanese Society of Neuroscience<
  • Japanese Society of Inflammation<
  • Foreign Member of Society for Neuroscience (U. S. A.)<
  • Member of American Society of Biochemistry & Molecular Biology<
  • Member of New York Academy of Science<
  • Member of American Association for the Advancement of Science (AAAS)<

Editor and Reviewer

  • Editorial Board of the Journal of Biological Chemistry 1997-2001, 2003-2007, 2010-<
  • Editor of FASEB Journal 1998-Present<
  • Editorial Board of Genes to Cells 1998-Present<
  • Ad hoc reviewer:<
    •    <Science, Nature, Nature Immunol., Eur. J. Biochem., Biochem. J., Cell, J. Neurosci., EMBO J.
  • Grant Committee of Human Frontier Science Program (1999-)<

Research Interest

  • Biosynthesis and Functions of Lipid Mediators (platelet-activating factor, leukotrienes, prostaglandins, lysophosphatidic acid, phospholipase A2)<
  • Roles of lipid mediators in self-defense and neural functions<

Selected list of publications since 1991.

  1. Honda, Z., Nakamura, M., Miki, I., Minami, M., Watanabe, T., Seyama, Y., Okado, H., Toh, H., Ito K., Miyamoto, T., and Shimizu, T: Cloning by functional expression of guinea pig lung platelet activating factor (PAF) receptor. Nature 349 342-346 (1991)
  2. Bito, H., Nakamura, M., Honda, Z., Izumi, T., Iwatsubo, T., Seyama, Y., Ogura, A., Kudo, H., and Shimizu, T: Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. Neuron 9 285-294 (1992)
  3. Yokomizo, T., Izumi, T., Takahashi, T., Kasama, T., Kobayashi, Y., Sato, F., and Shimizu, T.: Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxy-dehydrogenase. J. Biol. Chem. 268. 18128-18135 (1993)
  4. Mutoh, H., Fukuda, T., Kitamoto, T., Masushige, S., Sasaki, H., Shimizu, T., and Kato, S: Tissue-specific response of the human platelet-activating factor receptor gene to retinoic acid and thyroid hormone by ﾊalternative promoter usage. Proc. Natl. Acad. Sci. U.S.A. 93, 774-779 (1996)
  5. Mori, M., Aihara, M., Kume, K., Hamanoue, M., Kohsaka, S., and Shimizu, T: Predominant expression of platelet-activating factor receptor in the rat brain microglia. J. Neurosci. 16, 3590-3600 (1996)
  6. Yokomizo, T., Izumi, T., Chang, K.K., Takuwa, Y., and Shimizu, T.: A G-protein coupled receptor for leukotriene B4 that mediates chemotaxis.Nature 387, 620-624 (1997)
  7. Uozumi, N., Kume, K., Nagase, T., Nakatani, N., Ishii, S., Tashiro, F., Komagata, Y., Maki, K., Ikuta, K., Ouchi, Y., Miyazaki, J., and Shimizu, T. A major role for cytosolic phospholipase A2 in allergic responses and parturition. Nature 390, 618-622 (1997)
  8. Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W-H., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada, M. and Shimizu, T. Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187, 1779-1788 (1998)
  9. Nagase, T., Ishii, S., Kume, K., Uozumi, N., Izumi, T., Ouchi, Y., and Shimizu, T. Platelet-activating factor mediated acid-induced lung injury in genetically-engineered mice. J. Clin. Invest. 104, 1071-1076 (1999)
  10. Noiri, E., Yokomizo, T., Nakao, A., Izumi, T., Fujita, T., Kimura, S., and Shimizu, T. A novel in vivo approach showing the chemotactic activity of leukotriene B4 in acute ischemic-reperfusion injury. Proc. Natl. Acad. Sci. USA 97, 823-828, (2000).
  11. Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y., and Shimizu, T. Acute lung injury by sepsis and acid aspiration: a key role of cytosolic phospholipase A2. Nature Immunol. 1, 42-46 （2000）
  12. Kato, K., Yokomizo, T., Izumi, T., and Shimizu, T. Cell-specific transcriptional regulation of human leukotriene B4 receptor gene. J. Exp. Med.192: 413-420 (2000).
  13. Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., and Shimizu, T. A second leukotriene B4 receptor, BLT2: a new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192: 421-432(2000).
  14. Takaku, K, Sonoshita, M., Sasaki, N., Uozumi, N., Doi, Y., Shimizu, T., and Taketo, M.M. Suppression of intestinal polyposis in Apc-716 knockout mice by an additional mutation in the cytosolic phospholipase A2 gene. J. Biol. Chem. 275, 34013-34016 (2000) (Accelerated publication)
  15. Yokomizo, T., Kato, K., Hagiya, H., Izumi, T., and Shimizu, T. (2001) Hydroxyeicosanoids bind to and activate the low-affinity leukotriene B4 receptor, BLT2. J. Biol. Chem. 276: 12454-12459.
  16. Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga, E., Ouchi, Y. and Shimizu, T. (2002) A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis. Nature Med. 8, 480-484
  17. Wong, DA, Kita, K., Uozumi, N., and Shimizu, T. (2002) Discrete role for cytosolic phospholipase A2a in platelets:studies using single and double knockout mutant mice of cytosolic and group IIA secretory phospholipase A2. J. Exp. Med. 196, 349-353.
  18. Miyaura,C. Inada, M, Matsumoto, C., Ohshiba, T. Uozumi, N., Shimizu, T., and Ito, A (2003). An essential role of cytosolic phospholipase A2a in prostaglandin E2-mediated bone resorption associated with inflammation. J. Exp. Med. 197, 1303-1310
  19. Hegen, M.,Sun, L, Uozumi, N., Kume, K., Goad, M. E., Nickerson-Nutter, C. L., Shimizu, T., and Clark, J. D. (2003) Cytosolic phospholipase !sa-deficient mice are resistant to collagen-induced arthritis. J. Exp. Med. 197, 1297-1302.
  20. Hikiji, H., Ishii, S., Shindou, H., Takato, T., and Shimizu, T. (2004) Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. J. Clin. Invest. 114, 85-93
  21. Marusic, S., Leach, M.W., Pelker, J.W., Azoitei, M.L., Uozumi, N., Cui, J., DeClercq, C.M., Shen, M.W.H., Miyashiro, J.S., Carito, B.A., Thakker, P., Simmons, D.L., Leonard, J.P., Shimizu, T., and Clark, J.D. (2005) Cytosolic phospholipase A2alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. J. Exp. Med. 202, 841-851
  22. Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., and Shimizu, T. (2005) Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. J. Exp. Med. 202, 853-863
  23. Yoshikawa, K., Kita, Y., Kishimoto, K., and Shimizu, T. (2006) Profiling of eicosanoid production in the rat hippocampus during kainate-induced seizure: Dual-phase regulation and differential involvement of cox-1 and cox-2. J. Clin. Invest. 281, 14663-14669
  24. Nakanishi, H., Shindou, H., Hishikawa, D., Harayama, T., Ogasawara, R., Suwabe, A., Taguchi, R., and Shimizu, T. (2006) Cloning and characterization of mouse lung-type acyl-coa:lysophosphatidylcholine acyltransferase 1 (LPCAT1): Expression in alveolar type II cells, and possible involvement in surfactant production. J. Biol. Chem. 281, 20140-20147
  25. Yanagida, K., Ishii, S., Hamano, F., Noguchi, K., and Shimizu, T. (2007) LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line. J. Biol. Chem. 282, 5814-5824
  26. Okuno, T., Iizuka, Y., Okazaki, H., Yokomizo, T., Taguchi, R., and Shimizu, T. (2008) 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2. J. Exp. Med. 205, 759-766
  27. Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T., and Karasuyama, H. (2008) Basophils play a pivotal role in IgG-, but not IgE-mediated systemic anaphylaxis in contrast to mast cells. Immunity 28, 581-589
  28. Harayama, T*., Shindou, H*. (*, equal contribution), Ogasawara, R., Suwabe, A, and Shimizu, T. (2008) Identification of a novel non-inflammatory biosynthetic pathway of platelet-activating factor. J. Biol. Chem 283, 11097-11106
  29. Hishikawa, D*., Shindou, H*. (*, equal contribution), Kobayashi, S., Nakanishi, H., Taguchi, R., and Shimizu, T. (2008) Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc. Natl. Acad. Sci. USA 105, 2830-2835
  30. Shindou H. and Shimizu T. (2009) Acyl-CoA:lysophospholipid acyltransferases. J. Biol. Chem 284, 1-5
  31. Kihara, Y., Matsushita, T., Kita, Y., Uematsu, S., Akira, S., Kira, J.-i., Ishii, S., and Shimizu, T. (2009) Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. Proc. Natl. Acad. Sci. USA 106, 21807-21812
  32. Hikiji, H., Ishii, S., Yokomizo, T., Takato, T., and Shimizu, T. (2009) A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc. Natl. Acad. Sci. USA 106, 21294-21299
  33. Shimizu, T. (2009) Lipid mediators in health and diseases. Ann. Rev. Pharmacol. Toxicol. 49, 123-150